A common question amongst scoliosis
sufferers, as well as those who suspect that they may be displaying signs of developing the condition, is “Is scoliosis hereditary?
As many of you will already be aware, most cases of scoliosis are defined as idiopathic, which means that the cause of the spinal curvature is unknown in the majority of patients. Despite this, research into the development of scoliosis has shown that there is a possible genetic link between family members, in cases where there is a family history of scoliosis.
Although it may not manifest itself as straightforwardly as other hereditary conditions, it is estimated that around 1 in 4 sufferers will have at least one other family member who also shows signs of scoliosis, and that first-degree relatives of scoliosis patients will have an 11 percent chance of developing the condition themselves.
Although the examination of inheritance patterns has helped to determine that scoliosis is a genetic as well as hereditary condition, it remains unclear which genes are responsible for the curvature itself. It is fairly certain, however, the condition is more likely to affect female family members, due to the prominence of the condition in females over males. For this reason, many believe scoliosis is hereditary but there is still plenty of research that needs to be completed to prove this.
At Scoliosis SOS we have treated instances of hereditary scoliosis in the past, in cases such as that of Tina Barlow, who travelled from Florida to receive treatment with us. Just days before her decision to enrol on one of our treatment courses, Tina’s daughter was also diagnosed with scoliosis, which came as an unwelcome revelation to Tina, who had struggled to manage her condition from the age of twelve. Knowing that this would give her daughter a chance at preventing her condition from deteriorating, Tina decided that they would both travel to Scoliosis SOS in order to receive treatment, and we are happy to report that they are both now living pain-free. To read Tina and her daughter’s full story, click here
Tina’s case is a great example of how non-surgical treatment can benefit family cases of scoliosis, as well as sufferers who are concerned about the future health of their children. Thanks to the integration of exercises which can be performed by the patients themselves, our ScolioGold treatment programme provides a lasting method of treatment that can be maintained by scoliosis sufferers, providing patients with the ability and knowledge to treat their symptoms.
We hope that has helped to answer the question of whether scoliosis is hereditary! If you have any questions about how we can help to treat family cases of scoliosis, or if you are a sufferer who is concerned that their child may require treatment for the condition, please feel free to get in touch via our contact page, to arrange a consultation.
There was potentially exciting news from Japan last month: researchers at Hiroshima University seem to have identified the gene that kick-starts the “genetic chain reaction” that eventually causes scoliosis.
As we’ve discussed previously
on this blog, the causes of scoliosis are often unclear. However, according to a report from Asian Scientist
, we are now one step closer to a solid answer: experiments on zebrafish have linked the development of scoliosis to an overactive gene called LBX1
It would seem that too much LBX1 activity can cause the spine to become misshapen as time progresses, resulting in scoliosis. This link is supported by the results of two different experiments:
- #1 – Researchers injected a group of zebrafish embryos with extra LBX1 proteins. In these embryos, the cells that would eventually become the fish’s backbone were notably wider than in embryos with normal LBX1 levels. The LBX1-boosted embryos that survived long enough to do so eventually developed misshapen bones in their backs, resulting in scoliosis.
- #2 – A second group of fish were genetically modified to promote extra LBX1 activity in some cells over the course of their lifetimes. Unlike the other group of embryos, some of these fish developed healthy backbones at first, but the spines still began to display a scoliotic curve as they grew older and entered adulthood.
The results of these experiments mirror the development of scoliosis in human beings; the first group of fish are analogous to people who are born with scoliosis, while experiment #2 offers a potential explanation for idiopathic scoliosis, which typically develops during adolescence.
(Even more intriguingly, the Hiroshima researchers noticed that their female test subjects were more likely to develop scoliosis than their male counterparts. Science has yet to provide a concrete explanation as to why scoliosis is more prevalent in women than in men, but it’s certainly interesting to learn that this phenomenon applies to zebrafish as well as to human beings.)
Naturally, it will take a lot more research before these findings can be used to treat scoliosis, but it is very exciting to see these strides being made. In the meantime, if you’d like to find out more about how scoliosis can be treated without the need for surgery, please visit our ScolioGold Therapy
page or contact us
to arrange an initial consultation at the Scoliosis SOS Clinic.